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MOST

Metabolic Optimization and Simulation Tool



MOST Version 2.0 alpha-3 has been released on June 27, 2016. View release history.

Download MOST Executable Jar

Download MOST for Linux

Download MOST Source Code from GitHub Repository

MOST now visualizes Model SEED models.


You must have Java version 1.7 or greater installed on your computer before running MOST. Click here for instructions on determining if Java is installed. Java can be downloaded from this website.

MOST executable jar can be used for Windows and Macintosh although issues have been reported regarding running analyses on Macintosh. Extract the zip into a folder and double-click the MOST.jar file to run MOST. To use the Ipopt solver with Macintosh, GFortran needs to be installed. See Instructions for Installing MOST for further instructions on setting up your system to run MOST.

If analyses do not work on Macintosh, click here to the download the MOST-alpha-13 installer for Macintosh. This is an older version that does not include visualization.


If the error message below is displayed when starting up MOST:

Image - Launch Error

click OK to close the error message and start MOST. When the program appears, click Options -> Set GLPK Properties (Alt+O then Alt+L), then click the "Reset to Defaults" button (Alt+R) then click the OK button (Alt+O or Enter). The error message will no longer be displayed.


Release Dates:

MOST Version 2.0 alpha-2 was released on June 16, 2016.
Download MOST Version 2.0 alpha-2 Executable Jar
Download MOST Version 2.0 alpha-2 for Linux
MOST Version 2.0 alpha-1 was released on May 18, 2016.
Download MOST Version 2.0 alpha-1 Executable Jar
Download MOST Version 2.0 alpha-1 for Linux
MOST_alpha-14 was never released but was completed on April 1, 2015, and contains bug fixes for MOST-alpha-13. MOST alpha-14 can be downloaded using the links below:
Download MOST alpha-14 Executable Jar
Download MOST alpha-14 for Linux
MOST_alpha-13 was released on May 19, 2015.
Download MOST alpha-13 Executable Jar
Download MOST alpha-13 for Linux
MOST_alpha-12 was released on February 7, 2015.
MOST_alpha-11 was released on September 30, 2014.
MOST_alpha-10 was released on August 1, 2014.
MOST_alpha-9 was released on July 19, 2014.
MOST_alpha-8 was released on June 20, 2014.
MOST_alpha-8 was released on June 7, 2014.
MOST_alpha-7 was released on May 29, 2014.
MOST_alpha-6 was released on March 29, 2014.

These releases are available on the MOST GitHub repository. Installers and jars can be found in the "dist" of each branch with the exception of MOST_alpha-14. The website associated with recent branches can be found in the "etc/backup/website" folder
MOST_alpha-14 uses the same website as MOST Version 2.0 alpha-1 but does not have visualization functionality.
MOST_alpha-12 installers and jars are only available in some commits made on May 19, 2015 and there is no installer for Mac.